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Utilising in silico, in vitro and ‘omics New Approach Methodologies (NAMs) for priority-setting and safety assessment of tropane alkaloids (TAs) and other plant toxins as potential food contaminants. A case study for progressing the acceptance of NAMs for

Food Standards Agency

Buyer Contact Info

Buyer Name: Food Standards Agency

Buyer Address: YO1 7PR, York, UKE21, YO1 7PR, United Kingdom

Contact Name: FSA Commercial

Contact Email: fsa.commercial@food.gov.uk

Status
complete
Procedure
direct
Value
488375.5 GBP
Published
27 Oct 2025, 15:26
Deadline
n/a
Contract Start
24 Sep 2025, 23:00
Contract End
31 May 2028, 22:59
Category
n/a
CPV
73110000 - Research services
Region
n/a
Awarded To
University of Birmingham
Official Source
Open Find a Tender

Description

Tenders were invited to carry out a range of project delivery options, to deliver against stages 1, 2 and 3 as described below: Stage 1: This case study is to support the UK FSA’s policy need to determine which TAs are the most potent (neuro)toxicants so as to prioritise specific substances and inform decisions on the UK’s monitoring of these alkaloids in foods. An integral part of this aim is to confirm that neurotoxicity is the primary mode of action of these alkaloids. This aim will be achieved using a tiered-testing strategy of in silico, in vitro and ‘omics NAMs. This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 2: To derive a HBGV for human exposure for the top priority, i.e. most potent substance within the class of TAs. This will utilise physiologically-based kinetic (PBK) modelling and quantitative in vitro to in vivo extrapolation (QIVIVE). This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 3: From a methodological perspective, a broader third objective of the case study is to evaluate and attempt to build confidence within the FSA in the application of a series of relevant NAMs that have been integrated in a manner to address policy needs. These NAMs are tiered and incorporate existing human in vivo data as well as new testing on human in vitro cell lines, to maximise the relevance and accuracy to human food safety. Please note contract start date is 22/09/2025

Linked Documents

No linked documents found for this notice.

Opportunity Context

Lots

Lot 1 Status: complete

Documents

Document Description: Not published

Contracts

Contract Title: Utilising in silico, in vitro and ‘omics New Approach Methodologies (NAMs) for

Raw Notice JSON

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