Research & Development Framework

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  "date": "2025-06-18T16:26:41+01:00",
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    "description": "The Chemicals Regulation Division (CRD) wishes to establish a new research and development (R\u0026D) framework with six specific lots (A-F).\nThis framework will be structured into specialism based lots. Each lot is designed to hold more than one supplier to allow a varied skill set across each lot. \n A specification will be written for each project and HSE will then consider the specification against each supplier to determine which supplier\u0027s expertise is best suited to the project. If more than one supplier has the relevant experience, a cab rank system will be used (further detail on this process is provided in section 4). Due to the nature of the type of R\u0026D projects that will be brought forward, we are aware that not all suppliers in a lot may necessarily be able to undertake all the projects brought forward, so this approach ensures projects will be allocated to the most relevant supplier.\nHSE reserve the right to allocate projects to other suppliers in the framework, outside of the specified lot, if all the suppliers allocated to a lot are not able to undertake the project.\nThis framework will be open to usage from all HSE teams. The framework will enable faster turnaround of R\u0026D. It also provides a more cost effective and less burdensome way of commissioning research projects.\nThe framework is designed to be a 4 year contract.\nWe are unsure how many times we will use each individual Lot on the R\u0026D Framework throughout the four year period. The award of each individual Lot does not guarantee any amount of work during the contract agreement period.  \nWhilst we anticipate using each individual Lot on the R\u0026D Framework to fulfil our needs, we do reserve the right to choose to commission such work through other means and with other suppliers as we see fit.\n3.\tSCOPE OF THE SERVICES REQUIRED\nThe R\u0026D Framework will be structured into 6 specialism based lots:\n\u2022\tLot A - Chemistry\n\u2022\tLot B - Ecotoxicology\n\u2022\tLot C - Efficacy\n\u2022\tLot D - Fate and Behaviour\n\u2022\tLot E - Residues\n\u2022\tLot F - Toxicology\nSuppliers may, apply for one, some or all of lots (A-F). We intend to appoint 4 suppliers for each lot.",
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        "description": "Lot A - Chemistry\nPrimary quantitative research and analysis\nAll types of primary quantitative research. To exemplify, primary methods may include (but not be limited to):\n\u00b7\tMethod development \n\u00b7\tApplication and validation of methods and techniques\n\u00b7\tAdaptation and extension of existing techniques\n\u00b7\tAssociated work such as: securing samples, interpreting data and results, \n\u00b7\tAnalyses, reporting and the generation of key scientific eoutcomes and recommendations from the work\nTo include, but not be limited to methods and approaches that enable the development of methods for the analysis of pesticide active substances, impurities and co-formulants in pesticide formulations, and of residues of pesticide active substances and metabolites  in food and feeds",
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        "description": "All types of secondary analysis. To exemplify, methods may include (but are not limited to): \n\u00b7\tDesk research\n\u00b7\tLiterature reviews\n\u00b7\tQuantitative summaries \n\u00b7\tSystematic reviews\n\u00b7\tHorizon scanning\n\u00b7\tPlus analyses, reporting and the generation of key scientific evidence, regulatory developments and recommendations from the work.\nTopics may include\n\u2022\tBirds\n\u2022\tMammals\n\u2022\tAquatic (including sediment) organisms\n\u2022\tBees and other polinators\n\u2022\tNon-target arthropods\n\u2022\tSoil organsims\n\u2022\tNon-target plants\n\u2022\tBiopesticides\n\u2022\tEndocrine disruption\n\u2022\tEffect modelling\n\u2022\tLinking exposure and effects\n\u2022\tNew technology \n\u2022\tRisk assessment for precision agriculture\n\u2022\tClimate change\n\u2022\tBioaccumulation\n\u2022\tBiodiversity\n\u2022\tProtection Goals\n\u2022\tRisk mitigation\n\u2022\tNovel / alternative application methods\n\u2022\tChemical mixtures and mulitple stressors\n\u2022\tLandscape scale assessment\n\u2022\tSublethal effects\n\u2022\tCommunity and ecosytstems",
        "id": "B",
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        "title": "Ecotoxicology",
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          "startDate": "2025-08-21T00:00:00+01:00"
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        "description": "\u2022\tEvidence on the impact of selection pressures exerted by the use of plant protection products on resistance development and the mechanisms of resistance.  Informing the development of resistance management strategies to support sustainable crop production. \n\u2022\tEvidence on developing novel and integrated approaches for the control of pests, weeds and diseases, taking into account any adaptation and mitigation measures arising from climate change, and what impact this may have on efficacy regulatory requirements.  \n\u2022\tEvidence on the impact of different application technologies on the efficacy of plant protection products, including impacts on resistance development, and what changes or adaptations to efficacy regulatory requirements may be needed.  \n\u2022\tEvaluating the scope of new technologies for assessing biological parameters in efficacy field trials. \n\u2022\tEvaluating the current and changing status of target species, cropping practices and PPP availability to inform the assessment of the agronomic relevance of PPPs and establish future challenges for pest and resistance management. \n\u2022\tThe impact of formulation chemistry on the biological efficacy of PPPs",
        "id": "C",
        "status": "active",
        "suitability": {
          "sme": true,
          "vcse": true
        },
        "title": "Efficacy",
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        "description": "All types of secondary analysis. To exemplify, methods may include (but are not limited to): \n\u00b7\tDesk research\n\u00b7\tLiterature reviews\n\u00b7\tQuantitative summaries \n\u00b7\tSystematic reviews\n\u00b7\tHorizon scanning\n\u00b7\tModel or software development\n\u00b7\tPlus analyses, reporting and the generation of key scientific evidence, regulatory developments and recommendations from the work.\n\u00b7\tProactive secondary collection (e.g. contacting organisations via phone/web to gather evidence and examples of practice - which may include interviews)\nTopics may include\n\u2022\tDegradation\n\u2022\tSorption\n\u2022\tEnvironmental fate and behaviour in soil, water, sediment, air\n\u2022\tRoutes of environmental exposure\n\u2022\tSpray drift\n\u2022\tRunoff\n\u2022\tDrainflow\n\u2022\tGroundwater leaching\n\u2022\tLong range transport\n\u2022\tPlant uptake\n\u2022\tPOPs and PBTs\n\u2022\tExposure modelling\n\u2022\tScenario development\n\u2022\tSurrogate crops\n\u2022\tLinking exposure and effects\n\u2022\tNew technology\n\u2022\tDrones\n\u2022\tNovel / alternative application methods\n\u2022\tCrop specific exposure assessments\n\u2022\tHard surfaces\n\u2022\tBiopesticides\n\u2022\tMetals\n\u2022\tMetabolites\n\u2022\tUnextracted residues\n\u2022\tClimate change\n\u2022\tRisk mitigation\n\u2022\tHigher tier modelling\n\u2022\tSpatial assessments\n\u2022\tLandscape or catchment scale exposure assessments\n\u2022\tWater treatment processes\n\u2022\tEnvironmental monitoring\n\u2022\tExposure assessment goals",
        "id": "D",
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          "endDate": "2029-08-20T23:59:59+01:00",
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        "description": "All types of secondary analysis. To exemplify, methods may include (but are not limited to): \n\u00b7\tDesk research\n\u00b7\tLiterature reviews\n\u00b7\tQuantitative summaries \n\u00b7\tSystematic reviews\n\u00b7\tHorizon scanning\n\u00b7\tPlus analyses, reporting and the generation of key scientific evidence, regulatory developments and recommendations from the work.\nTopics may include\n\u2022\tImpact of new application techniques, including drones on residue levels in crops\n\u2022\tStorage stability \n\u2022\tMetabolism in plants and animals, including fish \n\u2022\tExtraction efficiency \n\u2022\tUncertainties within the residues assessment, MRL setting and consumer risk assessments\n\u2022\tResidue trial parameters, and their impact on residue levels\n\u2022\tProportionaility/ scaling of residues\n\u2022\tCrop to crop extrapolations \n\u2022\tImpact of processing\n\u2022\tResidues in rotational crops\n\u2022\tResidues in honey and other bee products\n\u2022\tResidues in fish, including the diets of farmed fish\n\u2022\tConsumption data \n\u2022\tApproaches to consumer risk assessments",
        "id": "E",
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        "title": "Residues",
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        "description": "All types of secondary analysis. To exemplify, methods may include (but are not limited to): \n\u00b7\tDesk research\n\u00b7\tLiterature reviews\n\u00b7\tQuantitative summaries \n\u00b7\tSystematic reviews\n\u00b7\tHorizon scanning\n\u00b7\tPlus analyses, reporting and the generation of key scientific evidence, regulatory developments and recommendations from the work.\nTopics may include\n\u2022\tAcute toxicity\n\u2022\tSkin and eye irritation\n\u2022\tSkin sensitisation\n\u2022\tPhototoxicity\n\u2022\tRepeated dose toxicity\n\u2022\tGenotoxicity\n\u2022\tCarcinogenicity\n\u2022\tReproductive toxicity\n\u2022\tDevelopmental neurotoxicity\n\u2022\tEndocrine disruption\n\u2022\tADME and dermal absorption\n\u2022\tModelling\n\u2022\tIn silico tools\n\u2022\tTTC approach\n\u2022\tNAMs\n\u2022\tEpidemiology\n\u2022\tUncertainty\n\u2022\tNGRA\n\u2022\tProtection Goals\n\u2022\tRisk mitigation\n\u2022\tRisk communication\n\u2022\tCo-formulants\n\u2022\t3Rs\n\u2022\tChemical mixtures \n\u2022\tBiopesticides\n\u2022\tAntimicrobial resistance\n\u2022\tEffects on the gut microbiome\n\u2022\tDose setting and maximum tolerated dose\n\u2022\tKinetically-informed maximum dose",
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